Officials told that gunmen ridding on motorcycle opened fire at Mehmood Jan Afridi in bus stand in Kalat town on Friday evening, killing him on the spot.
The attackers escaped from the area after killing the journalist, they added.
Security forces cordoned off the area and started search operation. Mehmood Jan Afridi was working as reporter with Daily Intekhab.
The killing incident of journalist comes two days after gunmen killed a senior journalist Malik Mumtaz in North Waziristan on Wednesday.
Mumtaz was returning home to Miranshah after offering condolences from a nearby village when unknown assailants opened fire on his car, killing him on the spot.